Nikephoros Melissenos was born ca. 1045. He was a military official and a scion of an aristocratic family of Asia Minor. In the autumn of 1080, he rebelled against the emperor Nikephoros III Botaneiates in Nicaea of Bithynia. He abandoned his imperial ambitions in April 1081 and acknowledged the power of his brother-in-law, Alexios I Komnenos, who honored him with the title of kaisaras. He died on November 17th, 1104.