18th century BC: Miletus is a thriving commercial Minoan harbour.
15th century BC: Miletus-Milawanda is involved in the conflictions between Achaeans and Hittites.
1185-1180 BC: Destruction of the Late Bronze Age Miletus.
1050 BC: Foundation of the Ionian city according to archaeological data.
8th century BC, end: Miletus participates in the war between Eretria and Chalcis over the control of the Lelantine Plain, supporting Eretria.
615 BC: Abolition of aristocracy and establishment of tyranny by Thrasybulus.
608 or 598 or 594 BC: After 12 years of conflicts, the Milesians signed a treaty of alliance with Alyattes of the Lydian Kingdom.
600-540 BC: A period of revolt.
546 BC: Miletus signed a treaty with Cyrus and did not react against the conquest of Asia Minor by the Persians.
540 or 525 BC: Establishment of oligarchy in Miletus.
513 BC: The Milesians under their tyrant Histiaeus participated in the Scythian expedition of Darius.
500 BC: Aristagoras of Miletus caused the Ionian Revolt.
494 BC: The Persians besieged Miletus and destroyed the city.
479 BC: Miletus took part beside the Persians in the naval battle of Mycale but they defected. The city was rebuilt in accordance with the plan of Hippodamus.
478 BC: Miletus joined the Delian League.
470-440 BC: A dispute divided the oligarchic side.
450/449 BC: Athens took measures to deal with the situation in Miletus. The oligarchs rebelled and massacred the democrats.
441 BC: Athens intervened again, favouring Miletus in a dispute with Samos.
430 BC: The regime in Miletus was democracy, according to the Athenian standards.
425-424 BC: Milesian soldiers took part in Athenian operations during the Peloponnesian War.
415-413 BC: Participation of Milesians in the Sicilian expedition.
412/411 BC: Miletus revolted against the Athenians after the intervention of Alcibiades. Miletus successfully repelled the attack of the Athenians.
405 BC: The Spartan admiral Lysander supported a bloody coup that imposed oligarchy again.
402 BC: Tissaphernes, satrap of Lydia, executed or exiled all the oligarchs who favoured Sparta, fearing that they would support Cyrus the Younger. Reestablishment of democracy.
386 BC: With the Peace of Antalcidas (386 BC) Miletus came finally under the Persian control.
370-334 BC: Miletus came under the control of the Hecatomnides, satraps of Caria.
334 BC: Alexander the Great besieged and conquered the city.
333 BC: The Persian fleet recaptured the city.
332 BC: Miletus was occupied again by the Macedonians under Balacrus.
312 BC: Antigonus I Monophtalmos freed the city from Asandrus, granted autonomy and restored the democratic regime.
300-299 BC: Seleucus I Nicator made substantial donations to the sanctuary of Didyma and returned the statue of Apollo.
295 BC: Demetrius Poliorcetes, son of Antigonus, was the eponymous archon (stephanephorus) in the city.
294 BC: The city allied with Ptolemy I.
286/285 BC: Miletus is under the control of Demetrius Poliorcetes.
285-281 BC: Lycimachus assumed control over Miletus.
280/279 BC: Αntiochus I is elected as the first eponymous archon of the period (stephanephorus).
262 BC: Antigonus II Gonatas unsuccessfully tried to detach the city from the Ptolemies.
261/260 BC: Ptolemy III revolted against his father Ptolemy II with the help of Timarchus, who imposed tyranny on Miletus.
260/259 BC: The Seleucids controlled Miletus again, while Antiochus II was offered divine honours as he had restored freedom and democracy by expelling the tyrant Timarchus.
246 BC: Miletus supported Seleucus II.
246-245 BC: Miletus came under Ptolemaic influence.
201 BC: Philip V of Macedonia captured Miletus, detached the territories of Myous from Miletus and gave them to neighbouring Magnesia ad Maeandrum.
191-190 BC: During the war between Antiochus III and the Romans (190 BC), the Milesians allied with Antiochus.
188 BC: Under the Peace of Apamea the city reoccupied the territories of Myous. The external policy of Miletus was actually controlled by Rhodes.
185 BC: War between Miletus and Heraclea on the one side and Magnesia and Priene on the other side.
167 BC: Miletus came under the influence of the Attalids, maintaining friendly relationships with the Seleucids.
129 BC: Miletus is a free and autonomous city in the province of Asia.
88-83 BC: In the Mithradatic War Miletus encountered serious difficulties.
83 BC: The city lost its freedom due to the initial alliance with the King of Pontus.
38 BC: The city became autonomous in the years of Mark Antony, who granted its freedom.
17 BC: Augustus is elected as eponymous archon (stephanephorus).
117 AD: The city participated in the Panhellenion, the league of the Greek cities established by Emperor Hadrian.
164 AD: Faustina visited Miletus and stayed in the city, offering donations.